Laboratory of Clinical Biophysics

Devoted to theoretical and experimental research of clinically relevant problems by including methods of physics.

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About our laboratory

The prime subject of work of the Laboratory of Clinical Biophysics is theoretical and experimental research of clinically important problems by using physical methods. We are committed to life-friendly methods and encourage cooperation between different areas of knowledge.

Recently, we have focused on the study of nanostructures that are shed from the cell membrane and become free-moving cellular nanovesicles (CNVs). CNVs are cellular fragments that travel to other cells in the same organism or in other organisms and interact with them. Thus, they mediate in the communication between microorganisms, plants, animals and humans. They represent the boundary between the living and the non-living. We study the mechanisms of CNV formation and the natural laws to which they are subject. The systems we are most interested in at the moment are blood and microalgae cultures.

We are developing mathematical models to describe the biomechanics of the locomotor system. The HIPSTRESS method is used to determine the contact pressure in the hip and in the hip prothesis. We also study the biomechanics of sagittal balance and the corresponding shape of the spine. Mathematical models are used to decribe various pathologies.

In other theoretical work we discuss electric double layer, elastomechanics of the membrane, self-assembly of molecules, stability of thin anisotropic structures (organic in inorganic nanotubes, strips in non-lamellar stacks). In experimental work, we consider giant phospholipid vesicles and nanostructures in blood and in microalgae cultures, especially nanotubes and pores.

Our experimental equipment is the Laboratory of Physics, Faculty of Electrical Engineering, Tržaška 25, 1000 Ljubljana, Slovenia, and at the Department of Orthopaedic Surgery, University Medical Centre Ljubljana, Zaloška 9, 1000 Ljubljana, Slovenia,